ncRNA name | hsa-miR-146a |
ncRNA Category | miRNA |
Disease name | diabetic retinopathy (DR) |
Species | Homo sapiens |
Tissues/Cell_line | human umbilical-vein endothelial cells (HUVECs) |
Methods | transfection, RT-PCR, ELISA, luciferase reporter assay |
Expression pattern | down-regulated |
Functional description | A total of 25 mmol/L glucose decreased miR-146a expression and increased FN expression compared with 5 mmol/L glucose in both cell types. miR-146a mimic transfection prevented such change, whereas miR-146a antagomir transfection in the cells in 5 mmol/L glucose caused FN upregulation. |
PubMed ID | 21885871 |
Year | 2011 |
Title | miR-146a-Mediated extracellular matrix protein production in chronic diabetes complications. |
Drug-related ncRNA | NO |
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